PRIMOS: AN INTEGRATED PLATFORM FOR EXPLORING PROTEIN-PROTEIN INTERACTIONS

Outline

T. Kern, M. Kommenda, V. Dorfer, J. W. Bauer, K. Oender - PRIMOS: AN INTEGRATED PLATFORM FOR EXPLORING PROTEIN-PROTEIN INTERACTIONS - Proceedings of 21st European Modeling and Simulation Symposium EMSS 2009, Tenerife, Spanien, 2009, pp. 6

Abstract

Knowledge of PPIs is the key to understanding cellular processes. The PRIMOS platform operates as a sophisticated knowledge portal for analysing protein-protein interaction data and more complex search options for diseases and their relationships to proteins and interactions. It currently integrates PPI data from six major PPI databases and detects both congruent and conflicting information. All imported PPIs are reassessed and categorized by a novel homology-based validation scheme. Additionally the interaction viewer can be started for every interacting protein within PRIMOS. Interaction networks are represented as graphs in which the nodes are the proteins and the edges are the interactions between these proteins.