Person

FH-Prof. Dr. Julian Weghuber

Education

Johannes Kepler University
Jan 2015 - Nov 2019
Universität Wien, Dr. rer. nat.
Oct 2002 - Dec 2005
Universität Wien, Biologie - Genetik, Mag.
Oct 1998 - Oct 2002
Gymnasium Kirchdorf/Krems
Sep 1990 - Jun 1998

Professional career & activities

Johannes Kepler University, Assistant professor
Nov 2019 - dato
FH OÖ Studienbetriebs GmbH, Professor für molecular cell physiology
Dec 2014 - dato
JKU Linz, Post Doc, fluorescence microscopy, detection of protein-protein-interactions
Dec 2005 - Dec 2010
2019
J. Weghuber, J. Pitsch - Hydrophilic interaction chromatography coupled with charged aerosol detection for simultaneous quantitation of carbohydrates, polyols and ions in food and beverages - Molecules, Vol. 11, No. 1, 2019 more
2019
R. Haselgrübler, P. Lanzerstorfer, C. Röhrl, F. Stübl, J. Schurr, B. Schwarzinger, C. Schwarzinger, M. Brameshuber, S. Wieser, S. M. Winkler, J. Weghuber - Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid… more
2019
P. Lanzerstorfer, J. Grasberger, G. Sandner, F. Stübl, J. Weghuber - A holistic approach for the toxicological assessment of phytogenic substances in human and animal nutrition. - ALTEX, Linz, Austria, 2019 more
2019
A. König, B. Schwarzinger, V. Stadlbauer, P. Lanzerstorfer, M. Iken, C. Schwarzinger, S. Schwarzinger, O. Höglinger, D. Weghuber, J. Weghuber - Glucose Resorption in a Double-Blind, Randomized Clinical Study - Nutrients, Vol. 11, No. 7, 2019 more
2019
H. Schneckenburger, P. Weber, M. Wagner, S. Enderle, B. Kalthof, L. Schneider, C. Herzog, J. Weghuber, P. Lanzerstorfer - Combining TIR and FRET in Molecular Test Systems - International Journal of Molecular Sciences, Vol. 20, No. 3, 2019 more
2018
Y. Yoneyama, P. Lanzerstorfer, F. Hakuno, J. Weghuber, S. Takahashi - IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling - eLIFE, 2018 more
2018
U. Müller, F. Stübl, B. Schwarzinger, G. Sandner, M. Iken, M. Himmelsbach, C. Schwarzinger, N. Ollinger, V. Stadlbauer, O. Höglinger, P. Lanzerstorfer, J. Weghuber - In vitro and in vivo inhibition of intestinal glucose transport by guava (Psidium guajava) extracts - Molecular nutrition and food research,… more
2018
R. Haselgrübler, F. Stübl, V. Stadlbauer, P. Lanzerstorfer, J. Weghuber - An In-ovo Model for Testing Insulin-Mimetic Compounds - JOVE, 2018 more
2018
P. Lanzerstorfer, E. Rechenmacher, O. Lugmayr, V. Stadlbauer, O. Höglinger, A. Vollmar, J. Weghuber - Effects of Various Commercial Whole-Grain Breads on Postprandial Blood Glucose Response and Glycemic Index in Healthy Subjects - Austin Journal of Clinical Medicine, Vol. 5, No. 1, 2018 more
2018
B. Plochberger, M. Axmann, C. Röhrl, J. Weghuber, M. Brameshuber, S. Mayr, R. Ros, R. Bittman, H. Stangl, G. Schütz - Direct observation of cargo transfer from HDL particles to the plasma membrane - ATHEROSCLEROSIS, 2018, pp. 53-59 more
2018
R. Haselgrübler, V. Stadlbauer, F. Stübl, B. Schwarzinger, I. Rudzionyte, M. Himmelsbach, M. Iken, J. Weghuber - Insulin Mimetic Properties of Extracts Prepared from Bellis perennis - MOLECULES, 2018 more
2017
J. Weghuber - Studying protein-protein interactions (PPIs) of receptor tyrosine kinases on µ-patterned surfaces - ÖGMBT meeting 2013, Innsbruck, Austria, 2017 more
2017
P. Lanzerstorfer, Y. Yoneyama, F. Hakuno, D. Zindel, U. Müller, C. Krasel, M. Bünemann, O. Höglinger, S. Takahashi, J. Weghuber - Analysis of Receptor Tyrosine Kinase and G-Protein Coupled Receptor Signaling Dynamics on Micro-Structured Surfaces - BIOPHYSICAL JOURNAL, Vol. 112, No. 3, 2017 more
2017
R. Wagner, G. Stübiger, D. Veigel, M. Wuczkowski, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, C. Singer, R. Colomer, B. Benhamu, M. Lopez-Rodrguez, P. Valent, T. Grunt - Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their… more
2017
H. Reyer, J. Zentek, K. Männer, I. Youssef, T. Aumiller, J. Weghuber, K. Wimmers, A. Müller - Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers - JOURNAL… more
2017
G. Schütz, J. Weghuber, P. Lanzerstorfer, E. Sevcsik - Protein Micropatterning Assay: Quantitative Analysis of Protein–Protein Interactions - Methods in Molecular Biology, 2017, pp. 261-270 more
2016
P. Lanzerstorfer, Y. Yoneyama, U. Müller, R. Haselgrübler, D. Zindel, O. Höglinger, F. Hakuno, C. Krasel, S. Takahashi, M. Bünemann, J. Weghuber - Analysis of Receptor Tyrosine Kinase and G-Protein Coupled Receptor Signaling Dynamics on Micro-Structured Surfaces - BIOPHYSICAL JOURNAL, Vol. 110, No.… more
2016
B. Hohensinn, R. Haselgrübler, U. Müller, V. Stadlbauer, P. Lanzerstorfer, G. Lirk, O. Höglinger, J. Weghuber - Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH - Nitric Oxide, Vol. 60, No. 1, 2016,… more
2016
F. Baumgart, A. Arnold, K. Leskovar, K. Staszek, M. Fölser, J. Weghuber, H. Stockinger, G. Schütz - Varying label density allows artifact-free analysis of membrane-protein nanoclusters - Nature Methods, Vol. 13, No. 2016, 2016, pp. 661-664 more
2016
B. Plochberger, C. Röhrl, H. Stangl, J. Preiner, P. Hinterdorfer, G. Schütz, J. Weghuber, E. Sezgin - Receptor-Mediated HDL-Lipid Uptake is Regulated by Elastic Properties of the Plasma Membrane - BIOPHYSICAL JOURNAL, Vol. 110, No. 3, 2016 more
2016
R. Wagner, G. Stübiger, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, R. Colomer, M. Regueiro Rodríguez, T. Grunt - Exploiting cross-talk between lipid metabolism and oncogenic signaling for treatment of ovarian cancer - EUROPEAN JOURNAL OF CANCER, Vol. 61, No. 1, 2016, pp.… more
2015
D. M. Borgmann, P. Lanzerstorfer, V. Stadlbauer, U. Müller, S. M. Winkler, J. Weghuber - Bioinformatic analysis of total internal reflection fluorescence microscopy (TIRFM) data in the context of type 2 diabetes and cancer signaling - Proceedings of the 23rd Annual International Conference on Intelligent… more
2015
U. Müller, P. Lanzerstorfer, A. Arnold, E. Sevcsik, G. Kreindl, O. Höglinger, G. Schütz, J. Weghuber - Novel strategies for micro-contact printing based protein-protein interaction detection. - BIOPHYSICAL JOURNAL, Vol. 108, No. 2, 2015, pp. 480-481 more
2015
P. Lanzerstorfer, U. Müller, D. Zindel, O. Höglinger, C. Krasel, M. Bünemann, J. Weghuber - Localization and dynamics of beta-adrenergic receptor mediated EGFR transactivation on micro-patterned surfaces - BIOPHYSICAL JOURNAL, Vol. 108, No. 2, 2015, pp. 95 more
2015
P. Lanzerstorfer, Y. Yoneyama, F. Hakuno, U. Müller, O. Höglinger, S. Takahashi, J. Weghuber - Analysis of insulin receptor substrate (IRS) signaling dynamics on micro-structured surfaces. - FEBS Journal, Vol. 282, No. 6, 2015, pp. 987-1005 more
2015
J. Weghuber - Quantitative Protein-Protein Interaction Detection - Report, FH OÖ F&E GmbH, Austria, 2015, pp. 19-21 more
2015
E. Sevcsik, M. Brameshuber, M. Fölser, J. Weghuber, A. Honigmann, G. Schütz - GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane - Nature Communications, Vol. 6, No. 6969, 2015 more
2015
S. M. Winkler, S. Schaller, D. M. Borgmann, V. Dorfer, M. Affenzeller, J. Jacak, H. Redl, J. Weghuber - Identification and classification of objects and motions in microscopy images of biological samples using heuristic algorithms in Studies in Computational Intelligence (Contributions to Book: Part/Chapter/Section… more
2015
J. Wruss, G. Waldenberger, S. Huemer, P. Uygun, P. Lanzerstorfer, U. Müller, O. Höglinger, J. Weghuber - Compositional characteristics of commercial beetroot products and beetroot juice prepared from seven beetroot varieties grown in Upper Austria - Journal of Food Composition and Analysis, Vol. 42,… more
2015
J. Wruss, P. Lanzerstorfer, S. Huemer, M. Himmelsbach, H. Mangge, O. Höglinger, D. Weghuber, J. Weghuber - Differences in pharmacokinetics of apple polyphenols after standardized oral consumption of unprocessed apple juice - Nutritional Journal, Vol. 14, No. 32, 2015 more
2015
D. Zindel, A. Butcher, S. Al-Sabah, P. Lanzerstorfer, J. Weghuber, A. Tobin, M. Bünemann, C. Krasel - Engineered Hyperphosphorylation of the β2-adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization - MOLECULAR PHARMACOLOGY, Vol. 87, No. 2, 2015, pp. 349-362 more
2014
P. Lanzerstorfer, V. Stadlbauer, L. Chtcheglova, R. Haselgrübler, D. M. Borgmann, J. Wruss, P. Hinterdorfer, K. Schröder, S. M. Winkler, O. Höglinger, J. Weghuber - Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy - BRITISH JOURNAL… more
2014
O. Höglinger, J. Weghuber - The substance behind "an apple a day" - The World of Food Ingredients, Vol. 2, No. 2, 2014 more
2014
P. Lanzerstorfer, U. Müller, M. Bünemann, G. Kreindl, C. Krasel, S. Takahashi, O. Höglinger, J. Weghuber - Micro-structured surfaces as a superior tool for the quantitative analysis of protein-protein interactions in living cells - American Society of Cell Biology Meeting, Philadelphia, United States… more
2014
P. Lanzerstorfer, J. Wruss, S. Huemer, A. Steininger, U. Müller, M. Himmelsbach, D. M. Borgmann, S. M. Winkler, O. Höglinger, J. Weghuber - Bioanalytical characterization of apple juice from 88 grafted and nongrafted apple varieties grown in Upper Austria - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,… more
2014
P. Lanzerstorfer, V. Stadlbauer, D. M. Borgmann, J. Wruss, K. Schröder, S. M. Winkler, O. Höglinger, J. Weghuber - Identification of Novel Insulin Mimetic Drugs by Quantitative TIRF Microscopy - Biophysical Society Meeting 2014, San Francisco, United States of America, 2014 more
2014
P. Lanzerstorfer, J. Wruss, S. Huemer, A. Steininger, U. Müller, M. Himmelsbach, D. M. Borgmann, S. M. Winkler, O. Höglinger, J. Weghuber - Bioanalytical Characterization of Apple Juice from 88 Grafted and Non-Grafted Apple Varieties Grown in Upper Austria. - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,… more
2014
V. Stadlbauer, P. Lanzerstorfer, D. M. Borgmann, J. Wruss, K. Schröder, S. M. Winkler, O. Höglinger, J. Weghuber - Total Internal Reflection Fluorescence (TIRF) Microscopy Guided Quantification of GLUT4 Translocation for the Identification of Insulin Mimetic Drugs - BIOPHYSICAL JOURNAL, Vol. 106, No.… more
2013
D. Gintner, O. Höglinger, J. Weghuber - Characterization of regulatory effects of fruit- and vegetable-juices on CYP450 gene expression levels - Proceedings FFH 2013, Dornbirn, Austria, 2013 more
2013
O. Höglinger, A. Steininger, P. Lanzerstorfer, J. Weghuber - Biophysical and biochemical characterization of insulin-dependent cellular systems in response to secondary plant metabolites - Proceedings FFH 2013, Dornbirn, Austria, 2013 more
2013
J. Weghuber - Studying protein-protein interactions of receptor tyrosine kinases studied on µ-patterned surfaces - Biophysical Society 57th Annual Meeting, Philadelphia, United States of America, 2013 more
2013
P. Lanzerstorfer, C. Krasel, O. Höglinger, J. Weghuber - Protein-protein interactions of the ß-adrenergic receptor and kinetic analysis of intracellular binding partners via µ-patterned surfaces - Protein-protein interactions of the ß-adrenergic receptor and kinetic analysis of intracellular binding… more
2012
S. Sunzenauer, V. Zojer, A. Tröls, M. Brameshuber, J. Weghuber, H. Stockinger, G. Schütz - Determination of binding curves via protein micropatterning in vitro and in living cells - CYTOMETRY, Vol. 1, No. 1, 2012 more
2012
D. Borgmann, J. Weghuber, S. Schaller, J. Jacak, S. M. Winkler - Identification of Patterns in Microscopy Images of Biological Samples using Evolution Strategies - Proceedings of the 24th European Modeling and Simulation Symposium EMSS 2012, Vienna, Austria, 2012, pp. 271-276 more
2012
P. Lanzerstorfer, S. Sunzenauer, M. Brameshuber, G. Schütz, S. Takahashi, M. Bünemann, O. Höglinger, J. Weghuber - Drug Screening on signal transduction proteins via µ-patterned surfaces - 56th Biophysical Society Meeting, San Diego, San Diego, United States of America, 2012 more
2012
P. Lanzerstorfer, D. M. Borgmann, A. Steininger, S. Schaller, M. Brameshuber, S. Sunzenauer, O. Höglinger, J. Weghuber - Analysis of Protein-Protein Interactions in Live Cells - The Micropatterning Approach in Basic Methods in Protein Purification and Analysis, 2012 more
2012
M. Kröppl, O. Höglinger, T. Kampitsch, P. Lanzerstorfer, J. Weghuber, B. Redl - Biochemical characterization of apple cultivars from Upper Austria - Biochemische Charakterisierung von Apfelsorten aus Oberösterreich - 67. ALVA-Jahrestagung , Wien, Wien, Austria, 2012 more
2012
P. Lanzerstorfer, O. Höglinger, J. Weghuber - Studying molecular effects of plant polyphenols on plasma-membrane localized signalling molecules - 67. ALVA Jahrestagung, Wien, Austria, 2012 more
2012
P. Lanzerstorfer, S. Sunzenauer, M. Brameshuber, G. Schütz, O. Höglinger, M. Bünemann, J. Weghuber - Multimerization studies of membrane receptors via µ-patterned surfaces - Biophysical Society meeting 2012, San Diego, United States of America, 2012 more
2012
P. Lanzerstorfer, S. Sunzenauer, M. Brameshuber, G. Schütz, S. Takahashi, M. Bünemann, O. Höglinger, J. Weghuber - Drug screening on signal transduction proteins via µ-patterned surfaces - Biophysical Society meeting 2012, San Diego, United States of America, 2012 more
2012
S. Schaller, J. Jacak, D. M. Borgmann, J. Weghuber, S. M. Winkler - An Image Analysis Suite for Automated Spot Detection in Cellular and Nano Structures of Microscopy Images - Proceedings of the 20th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB), Long Beach, CA,… more
2012
S. Schaller, S. M. Winkler, J. Weghuber, M. Sams, J. Jacak - µDetect: Design of a Framework for Optimized Structure Analysis in Fluorescence Microscopy Images - Proceedings of 6th FFH 2012, Graz, Austria, 2012, pp. 125-129 more
2011
J. Weghuber - Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells - VACCINE, Vol. 29, No. 3, 2011, pp. 426-436 more
2011
J. Weghuber, M. Aichinger, M. Brameshuber, S. Wieser, V. Ruprecht, B. Plochberger, J. Madl, A. Horner, S. Reipert, K. Lohner, T. Henics, G. Schütz - Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells - BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,… more
2011
P. Lanzerstorfer, S. Sunzenauer, G. Schütz, M. Bünemann, S. Takahashi, O. Höglinger, J. Weghuber - Drug Screening on signal transduction proteins via µ-patterned surfaces - EMBO Meeting, Wien, Austria, 2011 more
2011
J. Weghuber - Studying protein-protein interactions (PPIs) of receptor tyrosine kinases on µ-patterned surfaces - EMBO Meeting, Wien, Austria, 2011 more
2010
J. Weghuber - Imaging of Mobile Long-lived Nanoplatforms in the Live Cell Plasma Membrane - JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 285, No. 53, 2010, pp. 2581-2590 more
2010
J. Weghuber - Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells - JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 285, No. 52, 2010 more
2010
J. Weghuber - Cholesterol SlOWS down the Lateral Mobility of an Oxidized Phospholipid in a Supported Lipid Bilayer - LANGMUIR, Vol. 26, No. 22, 2010 more
2010
J. Weghuber - Antimicrobial and immunostimulatory peptide, KLK, induces an increase in cytosolic Ca(2+) concentration by mobilizing Ca(2+) from intracellular stores - CELL BIOLOGY INTERNATIONAL, Vol. 34, No. 11, 2010 more
2010
J. Weghuber - Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg(2+) channel - FEBS Journal, Vol. 277, No. 17, 2010 more
2010
J. Weghuber - Temporal resolution of protein-protein interactions in the live-cell plasma membrane - Analytical and Bioanalytical Chemistry, Vol. 387, No. 8, 2010 more
2010
J. Weghuber - Direct Observation and Quantitative Analysis of Lck Exchange between Plasma Membrane and Cytosol in Living T Cells - JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 285, No. 9, 2010 more
2010
J. Weghuber - in-vivo detection of protein-protein interactions on micro-patterned surfaces - Journal of Visualized Experiments, Vol. 3, No. 19, 2010 more
2010
J. Weghuber - DETECTION OF PROTEIN-PROTEIN INTERACTIONS IN THE LIVE CELL PLASMA MEMBRANE BY QUANTIFYING PREY REDISTRIBUTION UPON BAIT MICROPATTERNING - METHODS IN ENZYMOLOGY, Vol. 2010, No. 472, 2010 more
2010
J. Weghuber - Measuring Colocalization by Dual Color Single Molecule Imaging: Thresholds, Error Rates, and Sensitivity in Advances in Planar Lipid Bilayers and Liposomes (Contributions to Book: Part/Chapter/Section 12), , 2010, pp. 21-24 more
2009
J. Weghuber - A Root-Expressed Magnesium Transporter of the MRS2/MGT Gene Family in Arabidopsis thaliana Allows for Growth in Low-Mg2+ Environments - PLANT CELL, Vol. 21, No. 12, 2009 more
2009
J. Weghuber - Reply to "Uncoupling diffusion and binding in FRAP experiments" - Nature Methods, Vol. 6, No. 3, 2009 more
2009
J. Weghuber - Cell-to-cell variability in the diffusion constants of the plasma membrane proteins CD59 and CD147 - Soft Matter, Vol. 5, No. 17, 2009 more
2008
J. Weghuber - Micropatterning for quantitative analysis of protein-protein interactions in living cells - Nature Methods, Vol. 5, No. 12, 2008 more
2008
J. Weghuber - Different Types of Cell-to-Cell Connections Mediated by Nanotubular Structures - BIOPHYSICAL JOURNAL, Vol. 95, No. 9, 2008 more
2007
J. Weghuber - Mrs2p forms a high conductance Mg2+ selective channel in mitochondria - BIOPHYSICAL JOURNAL, Vol. 93, No. 11, 2007 more
2006
J. Weghuber - Mutational analysis of functional domains in Mrs2p, the mitochondrial Mg2+ channel protein of Saccharomyces cerevisiae - FEBS Journal, Vol. 273, No. 6, 2006 more
2003
J. Weghuber - Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria - EMBO JOURNAL, Vol. 22, No. 6, 2003 more
2017
The FFG programme line stipulates that COMET K1-Centres should be formed betweenscience and industry and that the work should be carried out on a competitive basis. Theproposed K1-Centre “Feed and… more
2017
The aim of this project is the development of innovative pharmaceutical tea products on the basis of selected tea varieties. These products shall be enriched in effective and scientifically well-documented… more
2017
2016
SLF
2015
Functional, caries-preventive drinks are being developed from beetroot and tested in a clinical trial in cooperation with the company Voglsam GmbH. more
2015
This project focuses on the development of functional foods and food supplements with pronounced insulin mimetic and/or intestinal glucose uptake inhibiting properties, which are crucial for the prevention… more
2014
We have recently introduced a method that is capable of detecting and quantifying protein-protein-interactions (PPIs) in a live cell context (Schwarzenbacher, Kaltenbrunner et al. 2008; Weghuber, Brameshuber… more
2013
2012
2011
Receptor proteins on the surface of human cells play a key role in the transmission of signals from the environment into the interior of the cell. A complex network of these proteins controls all cellular… more