Research Field

Medical Engineering

Research Field

The Department of Medical Engineering (Medical Engineering) is a national and international R & D partner for the development and manufacture of medical devices. We cooperate with manufacturers and suppliers. New technologies for medical applications are also being researched and evaluated for health care facilities. The work is carried out according to the European state of the art (harmonized standards), fulfilling the essential requirements of medical devices according to MDD, AAIMDD and IVDD.

The following research areas and special laboratories are operated:

• ReSSL - Hybrid simulators for surgery
Real-time simulators for the training and training of doctors

The new research and development of hybrid surgical simulators is the aim of the new research group ReSSL (Research Group for Surgical Simulators Linz). Hybrid simulators represent a combination of model- and computer-based simulation systems and combine their advantages. Using a computer model, users can visualize morphological structures and physiological processes in detail. Physical anatomical patient models provide a realistic haptic for the trained surgeon, thus the advantages of the desired development. Navigation systems allow real-time detection of the position of instruments, implants and anatomical structures. Together with the 3D data of anatomical patient models and instruments, imaging is also possible without X-ray radiation using suitable algorithms. The objective is to evaluate and analyze the surgical procedure. In addition to measuring the mechanical stresses of critical anatomical structures - such as nerves - it is also possible to simulate bleeding.

• MotionLab Motion analysis
Investigate movement patterns and patterns for rehabilitation, health care and aging society

Movements are - properly executed - essential to stay healthy. Too little movement leads directly to weight problems, and an incorrect sitting position in the office usually ends with chronic back problems.
In our "Movement and Prosthetics Laboratory" we use state-of-the-art technical methods for quantitative movement detection. Not only expensive, high-precision sensors are used, but also technologies from the entertainment industry, such as the Nintendo Wii or the Microsoft Kinect. For the evaluation of the data we work closely with practicing therapists, physicians and with clinical researchers to optimize the clinical diagnosis as well as the therapy for movement disorders.

 • Prosthetics
Intelligent prostheses and neuro-coupling

The research area deals with the development of arm and leg prostheses, which give people with amputations as much mobility and independence as possible. The technical orientation of the research is divided into the areas of sensor technology (sensation with prostheses), motorics (control of the prostheses) and prosthesis attachment (securing the prostheses to the body). In order to restore motor functions, separated nerves are coupled to the prostheses and the interaction between the prosthesis and the human being is investigated using artificial neural networks. In order to improve the wearing comfort of the prostheses, attachment variants on the amputation stump are examined and the causes of the frequently stressful (weather-dependent) phantom and neuroma pain are imitated. The research is carried out with the intensive involvement of people with amputations with the aim of continuously evaluating research results on their practical usability and utilizing them in cooperation with the industry.

 • 3D / microscopy laboratory
High-resolution microscopy as a supplement to imaging methods in medicine
Research concentrates on methodological aspects
• Biomechanics,
• Biosignal analysis and processing,
• Biomedical microscopy (3D fluorescence, AFM, et al.),
• Miniaturized electronics, measurement technology and sensor technology,
• Modeling and simulation,
• Further development of standards for the production of medical software and medical IT systems.


2018
M. Hollensteiner, D. Fürst, P. Augat, F. Schrödl, B. Esterer, S. Gabauer, S. Hunger, M. Malek, D. Stephan, A. Schrempf - Characterization of an Artificial Skull Cap for Cranio-Maxillofacial Surgery Training - JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol. 29, No. 9, 2018 more
2018
S. Senck, P. Weißenbacher, J. Kastner, T. Reiter, S. Hofstaetter, K. Trieb, E. Kranioti - Assessment of trabecular microstructure and mechanical properties in the intermediate cuneiform of healthy and diabetic patients using microcomputed tomography - 8th World Congress of Biomechanics, Dublin, Ireland,… more
2018
T. Haslwanter - 3D Kinematics - Springer International Publishing, 2018 more
2018
M. Hollensteiner, M. Botzenmayer, D. Fürst, M. Winkler, P. Augat, S. Sandriesser, F. Schrödl, B. Esterer, S. Gabauer, K. Püschel, A. Schrempf - Characterization of polyurethane-based synthetic vertebrae for spinal cement augmentation training - Journal of Materials Science: Materials in Medicine,… more
2018
M. Hollensteiner, P. Augat, D. Fürst, B. Esterer, S. Gabauer, M. Malek, S. Hunger, F. Schrödl, A. Schrempf - Validation of a Simulator for Cranial Graft Lift Training: Face, Content, and Construct Validity - Journal of Cranio-Maxillo-Facial Surgery, Vol. 46, No. 8, 2018, pp. 1390-1394 more
2018
D. Kytýř, P. Zlámal, P. Koudelka, T. Doktor, I. Kumpová, M. Vopálenský, P. Heimel, S. Mühleder, S. Senck - X-ray-based Microstructural Analysis of Low Atenuaing Biocompaible Porous Materials under Simulated Physiological Condiions - Proceedings of the 8th Conference on Industrial Computed Tomography,… more
2018
F. Hauser, S. Mayr, A. Tauscher, J. Jacak - Statistical analysis of 3D localization microscopy data for quantification of protein distribution upon clot formation - Proceedings of 8th Single Molecule Localization Microscopy Symposium, Harnack-Haus, Berlin, Germany, 2018 more
2017
M. Hollensteiner, D. Fürst, B. Esterer, P. Augat, F. Schrödl, S. Hunger, M. Malek, D. Stephan, A. Schrempf - Novel bone surrogates for cranial surgery training - J Mech Behav Biomed Mater, Vol. 72, No. 1, 2017, pp. 49-51 more
2017
M. Hollensteiner, P. Augat, D. Fürst, B. Esterer, S. Gabauer, K. Püschel, F. Schrödl, A. Schrempf - Novel synthetic vertebrae provide realistic haptics for pedicle screw placement - Proceedings of the PMU Science Get Together 2017, Nürnberg, Nürnberg, Germany, 2017 more
2017
M. Hollensteiner, D. Fürst, B. Esterer, S. Gabauer, P. Augat, F. Schrödl, A. Schrempf - Novel Simulator for Cranial Graft Lift Training - Proceedings of the IAUP Triennial Conference, Wien, Austria, 2017, pp. 25-27 more
2017
B. Schwartz, J. Kapellusch, A. Schrempf, K. Probst, M. Haller, A. Baca - Effect of alternating postures on cognitive performance for healthy people performing sedentary work - ERGONOMICS, Vol. 1, No. 40, 2017, pp. 778-795 more
2017
R. Wollhofen, B. Buchegger, J. Jacak, J. Kreutzer, T. Klar - Functional photoresists for sub-diffraction stimulated emission depletion lithography - OPTICAL MATERIALS EXPRESS , Vol. 7, No. 7, 2017, pp. 1-23 more
2017
C. Plamadeala, R. Wollhofen, J. Jacak, J. Heitz, T. Klar - Bioinspired polymer microstructures for directional transport of oily liquids - Royal Society Open Science, Vol. 10, No. 1098, 2017 more
2017
G. Langer, B. Buchegger, J. Jacak, T. Klar, T. Berer - Frequency domain optical resolution photoacoustic and fluorescence microscopy using a modulated laser diode - SPIE BiOS 2017 , San Francisco, United States of America, 2017 more
2017
G. Langer, B. Buchegger, J. Jacak, T. Klar, T. Berer - Multimodal fluorescence and photoacoustic microscopy in the frequency domain - SPIE BiOS 2017 , San Francisco, United States of America, 2017 more
2017
J. Kreutzer, B. Buchegger, J. Jacak, T. Klar, R. Wollhofen - 3D STED lithography: Protein binding and non-binding - SPIE BiOS 2017 , San Francisco, United States of America, 2017 more
2017
M. Hollensteiner, P. Augat, D. Fürst, B. Esterer, S. Gabauer, K. Püschel, F. Schrödl, A. Schrempf - Novel synthetic vertebrae provide realistic haptics for pedicle screw placement - Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Jeju,… more
2017
M. Hollensteiner - Development and Validation of Bone Surrogates for Tabula Externa Graft Lift Training - Phd Thesis, Paracelsus Medizinische Privat Universität Salzburg, Austria, 2017 more
2017
C. Crema, A. Depari, A. Flammini, E. Sisinni, T. Haslwanter, C. Crema - IMU-based solution for automatic detection and classification of exercises in the fitness scenario - 2017 IEEE Sensors Applications Symposium (SAS), Glasboro, United States of America, 2017 more
2016
J. Jacak, R. Wollhofen, T. Klar - Functional polymer scaffolds for biomolecule immobilization - SPIE Photonics Europe Proc., Brüssel, Belgium, 2016, pp. 1-6 more
2016
J. Jacak, R. Wollhofen, T. Klar - STED lithography for applications in biology - Proc. Photonics West Conference 9759 (Advanced Fabrication Technologies for Micro/Nano Optics and Photonics), San Francisco, United States of America, 2016, pp. 102-108 more
2016
J. Heitz, C. Plamadeala, M. Wiesbauer, R. Wollhofen, J. Jacak, T. Klar - Bone-forming cells with pronounced spread into the third dimension in polymer scaffolds fabricated by two-photon polymerization - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 1002, No. 35959, 2016 more
2016
B. Aekbote, T. Fekete, J. Jacak, G. Vizsnyiczai, P. Ormos, L. Kelemen - Surface-modified complex SU-8 microstructures for indirect optical manipulation of single cells - Biomedical Optics Express, Vol. 7, No. 1, 2016, pp. 45-56 more
2016
B. Schwartz, J. Kapellusch, A. Schrempf, K. Probst, M. Haller, A. Baca - Effect of a novel two-desk sit-to-stand workplace (ACTIVE OFFICE) on sitting time, performance and physiological parameters: protocol for a randomized control trial - BMC Public Health, Vol. 16, No. 1, 2016, pp. 578-588 more
2016
G. Langer, B. Buchegger, J. Jacak, T. Berer - Frequency domain photoacoustic and fluorescence microscopy - Biomedical Optics Express, Vol. 7, No. 2692, 2016, pp. 37-43 more
2016
M. Hollensteiner, D. Fürst, B. Esterer, S. Hunger, M. Malek, P. Augat, F. Schrödl, D. Stephan, A. Schrempf - Development of parietal bone surrogates for parietal graft lift training - CDBME, Vol. 2, No. 1, 2016, pp. 637-641 more
2016
S. Salzmann, T. Haslwanter, E. Baur, T. Bauer, H. Egger - A novel approach for a sensitive prosthetic leg – A case study - OT World, Leipzig, Germany, 2016 more
2016
S. Salzmann, H. Egger, E. Baur, T. Bauer, T. Haslwanter - A novel approach for a touch-sensitve prosthetic leg - Cybathlon Symposium, Zürich, Switzerland, 2016 more
2015
K. Hubatka, T. Haslwanter, M. Ehrenmüller, M. Ring - Evaluation of new market potentials for diagsnostic tools, for a video-based analysis system for the corneal tearfilm. - Proceedings 9th conference for Austrian universities of applied sciences, Hagenberg, Austria, 2015 more
2015
C. Wolfesberger, R. Wollhofen, B. Buchegger, J. Jacak, T. Klar - Streptavidin functionalized polymer nanodots fabricated by visible light lithography - Journal of Nanobiotechnology , Vol. 13, No. 1, 2015 more
2015
B. Buchegger, J. Kreutzer, J. Jacak, B. Plochberger, R. Wollhofen, U. Schubert, G. Schütz, T. Klar - STED-Lithography with Mercapto-Functional Polymers - ACS Nano, Vol. 10, No. 9, 2015 more
2015
B. Schwartz - Cognitive and biomechanical effects of postural changes in office environments - Cognitive and biomechanical effects of postural changes in office environments, Karlsruhe, Austria, 2015, pp. 1-6 more
2014
G. Mantokoudis, A. Tehrani, D. Zee, K. Eibenberger, A. Wozniak, C. Guede, J. Kattah, D. Newman-Toker - VOR Gain by Head Impulse Video-Oculography Differentiates Acute Vestibular Neuritis from Stroke - Otology Neurotology, Vol. 42, No. 2, 2014 more
2014
K. Eibenberger, G. Mantokoudis, A. Tehrani, J. Kattah, C. Guede, D. Zee, D. Newman-Toker - Quantifying the Vestibular Ocular Reflex with Video-Oculography: Nature and Frequency of Artifacts - Audiology & Neurootology, Vol. 1, No. 35, 2014 more
2014
K. Eibenberger, M. Schubert, B. Eibenberger, D. Roberts, T. Haslwanter, J. Carey - New High Acceleration Automatic Whole Body Impulse Test Reveals VOR Asymmetries not Detectable with Manual Head Impulse Testing - Society of Neuroscience Meeting 2014, Washington, United States of America, 2014 more
2014
K. Eibenberger, B. Eibenberger, D. Roberts, J. Carey, T. Haslwanter - Measuring Eye Movements for Vestibular and Oculomotor Research - Oculomotor Meeting, Zürich, Austria, 2014 more
2014
T. Rumetshofer, T. Haslwanter, M. Lehner - Internet database for assistive technologies - Internet Database for Assistive Technologies, Linz, Austria, 2014, pp. 125-127 more
2014
H. Egger, T. Haslwanter, R. Merwa - Thought control of machines - Modern Technologies for Disabled People - Thought control of machines - Modern Technologies for disabled people, Linz, Austria, 2014, pp. 118-121 more
2014
J. Jacak, J. Göhring, N. Fulcher, A. Barta - Suitable transfection methods for single particle tracing in plant suspension cells - Plant Methods, Vol. 10, No. 1, 2014 more
2014
J. Jacak, M. Sams, L. Muresan, R. Silye, K. Schilcher - Spatial cluster analysis of nanoscopically mapped serotonin receptors for classification of fixed brain tissue - Journal of Biomedical Optics, Vol. 19, No. 1, 2014 more
2013
M. Hollensteiner, D. Fürst, A. Schrempf - Artificial Vertebrae for a Novel Simulator in Minimally Invasive Spine Surgery - Biomedical Engineering , Graz, Austria, 2013, pp. 4409-4410 more
2013
B. Schwartz, A. Schrempf, K. Probst, M. Haller, J. Glöckl - Recognizing Static and Dynamic Sitting Behavior by Means of Instrumented Office Chairs - Proceedings of the 10th IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, Austria, 2013 more
2013
J. Göhring, J. Jacak, N. Fulcher - TeloTool: A New Tool for Telomere Length Measurement from Terminal Restriction Fragment (TRF) Analysis with Improved Probe Intensity - NUCLEIC ACIDS RESEARCH, Vol. 42, No. 3, 2013 more
2013
J. Jacak, M. Wiesbauer, R. Wollhofen, B. Vasic, K. Schilcher, T. Klar - Nano-Anchors with Single Protein Capacity Produced with STED Lithography - Nano Letters , Vol. 13, No. 11, 2013 more
2013
J. Jacak, H. Schnidar, L. Muresan, F. Aberger, G. Schütz, J. Hesse - Expression analysis of multiple myeloma cancer stem cells using single molecule microarray readout - JOURNAL OF BIOTECHNOLOGY, Vol. 164, No. 4, 2013 more
2012
M. Ring, D. Rabensteiner, J. Horwath-Winter, I. Boldin, R. Hoerantner, T. Haslwanter - Introducing a new parameter for the assessment of the tear film lipid layer - INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 53, No. 10, 2012, pp. 6638-6644 more
2012
T. Minarik, C. Hofer, A. Schrempf - A Novel Activity Monitoring Device for Home Rehabilitation Applications - Proceedings of the 9-th IASTED Conference on Biomedical Engineering, Innsbruck, Austria, 2012 more
2012
D. Fürst, A. Schrempf - PatientSIM - Development of an Augmented Reality Simulator for Surgical Training of Vertebroplasty and Kyphoplasty - Proceedings of the 9-th IASTED Conference on Biomedical Engineering, Innsbruck, Austria, 2012 more
2012
D. Fürst, D. Stephan, A. Schrempf, P. Augat - Foam Phantom Development for Artificial Vertebrae Used for Surgical Training - IEEE EMBS Annual International Conference , San Diego, United States of America, 2012 more
2012
A. Schrempf, G. Schoßleitner - Measuring Nightly Activity, Body Weight and Body Weight Change Rate with a Sensor Equipped Bed - IEEE EMBS Annual International Conference , San Diego, United States of America, 2012 more
2012
J. Jacak, Z. Szegletes, P. Ormos, G. Schütz - Aminosilane-based functionalization of two-photon polymerized SU-8 microstructures - EUROPEAN POLYMER JOURNAL, Vol. 48, No. 10, 2012 more
2012
K. Probst - Active Office: Towards an Activity-Promoting Office Workplace Design - CHI EA '12: Proceedings of the 2012 ACM annual conference extended abstracts on Human Factors in Computing Systems Extended Abstracts, Austin, United States of America, 2012, pp. 2165-2170 more
2011
M. Haller, C. Richter, P. Brandl, S. Gross, G. Schoßleitner, A. Schrempf - Finding the right way for interrupting people improving their sitting posture - Lecture Notes in Computer Science, Human-Computer Interaction – INTERACT 2011, Lisabon, Portugal, 2011 more
2011
A. Schrempf, G. Schoßleitner, T. Minarik, M. Haller, S. Gross - PostureCare - Towards a novel system for posture monitoring and guidance - Proceedings of the 18-th IFAC World Congress, Milan, Milan, Italy, 2011 more
2010
J. K. Y. Ong, T. Haslwanter - Measuring torsional eye movements by tracking stable iris features - JOURNAL OF NEUROSCIENCE METHODS, Vol. 192, No. 2, 2010, pp. 261-267 more
2010
A. Schrempf - Individual Assessment of the Training Intensity with Application to Physical Rehabilitation - 3-Länder-Tagung D-A-CH Gesellschaft für Biomedizinische Technik, Rostock, Germany, 2010 more
2009
T. Haslwanter, J. K. Y. Ong - Measuring torsion by tracking stable iris features - 2009 Neuroscience Meeting , Chicago, United States of America, 2009 more
2009
T. Haslwanter, M. Platz, J. K. Y. Ong - Optimizing Video-Oculography Systems by Simulating the Effect of Slippage Artifacts - Proceedings of 21st European Modeling and Simulation Symposium EMSS 2009, Tenerife, Spain, 2009 more
2009
J. K. Y. Ong, T. Haslwanter - Applying Knowledge—Challenges in Bringing Scientific Advances to Dizzy Patients - ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol. 1164, No. 1, 2009, pp. 309-315 more
2018
2017
Information about movement in everyday life can be obtained either with inertial sensors, or through measurements of the pressure on the sole of the foot. In cooperation with our partner in the Dept.… more
2017
The aim of this project is to expand the infrastructural and methodological basis for novel diagnostics and drug development. Innovative biological models and tools such as CRISR/Cas9 are being established… more
2017
Currently, there is an increased use of monoclonal antibodies in the context of the treatment of patients that suffer from cancer. In cooperation with a leading, internationally operating pharma company,… more
2017
Exosomes are nanoparticles that act as "transporters" between cells and even organs. By means of high-resolution fluorescence microscopy methods a highly precise localization and tracking of the… more
2017
In cooperation with our partners Otto-Bock and the Med-Uni Wien we investigate if sensory feedback for leg prothesis helps partners with amputations of the lower extremities to measurably improve their… more
2016
Within the interregional project Czech-Austrian Center for Supracellular Medical Research funded by the European Union we established a new facility regarding the production of blood vessel mimicking structures.Currently,… more
2016
In cooperation with the Medical University of Vienna and the University of New South Wales in Sydney, high-resolution microscopy techniques are used to characterize nanolevel microRNA communication between… more
2016
2015
Medical education is characterized by a time and cost intensive interaction between medical experts and trainees. According to demography the number of cases as well as the costs will increase. These demographic… more
2015
Transfusion of platelets is used either prophylactic to reduce the risk of clinical threatening bleedings or therapeutic to treat acute life-threatening thrombocytopathic-relevant bleedings (e.g. thrombocytopenic… more
2011
2011
2010
The FITREHAB projext will integrate and field test a new and innovative virtual reality based rehabilitation and training platform, which will allow patients and medical discharchged people to perform… more
2010
The basic approach of this project is to investigate the increase of overall quality, efficiency and effectiveness of physiotherapy to be achievable by introducing mechatronics based rehabilitation equipment… more
2009
2007