Oct 2011 - Dec 2014
Receptor proteins on the surface of human cells play a key role in the transmission of signals from the environment into the interior of the cell. A complex network of these proteins controls all cellular processes. The receptors themselves are activated and deactivated via different messengers and drugs: many medically relevant drugs bind to receptors and thus bring about certain changes in individual cells and, in further consequence, in organs or the entire organism. However, a group of drugs that are already long known in their molecular mode of action, but are explored only in little extent, are secondary plant substances.

The automatic extraction of relevant structures from different pictures is a challenge not only, but also in this research context. Applications for this particular task are not only found in medicine and biology (for example, in the automatic recognition of cells in human tissue), but also in physics (e.g., in the analysis of metals).

In this project the effect of secondary plant substances is to be analyzed for medically relevant surface molecules of human cells by means of a novel biophysical measurement method. Bioinformatic algorithms to quantify the recorded data will be developed and established in the scientific community. The aim of this project is beyond the implementation of a freely available, powerful frameworks for the detection of structures microscopy images. The image processing and analysis steps used should be configurable and combinable, the optimization of the parameters and the sequence of the algorithms used here shall (if desired) be run automatically without any user interaction.

Research program

UA Basic Promotion

This project ist co-financed by research subsidies granted by the government of Upper Austria. 
J. Jacak, R. Wollhofen, T. Klar - Functional polymer scaffolds for biomolecule immobilization - SPIE Photonics Europe Proc., Brüssel, Belgium, 2016, pp. 1-6 more
C. Wolfesberger, R. Wollhofen, B. Buchegger, J. Jacak, T. Klar - Streptavidin functionalized polymer nanodots fabricated by visible light lithography - Journal of Nanobiotechnology , Vol. 13, No. 1, 2015 more
S. Schaller, J. Jacak, D. M. Borgmann, J. Weghuber, S. M. Winkler - An Image Analysis Suite for Automated Spot Detection in Cellular and Nano Structures of Microscopy Images - Proceedings of the 20th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB), Long Beach, CA,… more
S. Schaller, S. M. Winkler, J. Weghuber, M. Sams, J. Jacak - µDetect: Design of a Framework for Optimized Structure Analysis in Fluorescence Microscopy Images - Proceedings of 6th FFH 2012, Graz, Austria, 2012, pp. 125-129 more
D. Borgmann, J. Weghuber, S. Schaller, J. Jacak, S. M. Winkler - Identification of Patterns in Microscopy Images of Biological Samples using Evolution Strategies - Proceedings of the 24th European Modeling and Simulation Symposium EMSS 2012, Vienna, Austria, 2012, pp. 271-276 more