Project

Plattform für die Diagnostik von Biomarkern und Analyse der Wirkstoffdynamik

Project

Jul 2017 - Sep 2020
The aim of this project is to expand the infrastructural and methodological basis for novel diagnostics and drug development. Innovative biological models and tools such as CRISR/Cas9 are being established to implement user projects at the interface of technology biology/medicine with physicians, diagnostics companies and drug developers.

Research program

IWB 2020


Das Projekt wurde im Rahmen des Strukturfondsprogramms „Investitionen in Wachstum und Beschäftigung Österreich 2014-2020 mit EU-Mitteln aus dem EFRE (Europäischer Fonds für Regionale Entwicklung) sowie aus Mitteln des Landes OÖ gefördert.

2018
A. Karner, K. Strohmeier, J. Preiner, W. Holnthoner, M. Mairhofer - Multi-technique approach for the characterization of exosomes - XX. Annual Linz Winter Workshop 2018, Linz, Austria, 2018 more
2017
A. Karner, J. Strasser, J. Preiner - High speed atomic force microscopy - imaging proteins in action - Proceedings of the XIX Annual Linz Winter Workshop 2017, Linz, Austria, 2017 more
2015
J. Preiner, A. Horner, A. Karner, N. Ollinger, C. Siligan, P. Pohl, P. Hinterdorfer - High-Speed AFM Images of Thermal Motion Provide Stiffness Map of Interfacial Membrane Protein Moieties - Nano Letters , Vol. 15, No. 1, 2015 more
2015
A. Horner, F. Zocher, J. Preiner, N. Ollinger, C. Siligan, S. Akimov, P. Pohl - The mobility of single‐file water molecules is governed by the number of H‐bonds they may form with channel‐ lining residues - Sciences Advances, 2015 more
2015
B. Nimmervoll, L. Chtcheglova, K. Juhasz, N. Cremades, F. Aprile, A. Sonnleitner, P. Hinterdorfer, L. Vigh, J. Preiner, Z. Balogi - Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis - FEBS LETTERS, 2015 more
2014
M. van Es, J. Tang, J. Preiner, P. Hinterdorfer, T. Oosterkamp - Single molecule binding dynamics measured with atomic force microscopy - Ultramicroscopy, 2014 more
2014
J. Preiner, N. Kodera, J. Tang, A. Ebner, M. Brameshuber, D. Blaas, N. Gelbmann, H. Gruber, T. Ando, P. Hinterdorfer - IgGs are made for walking on bacterial and viral surfaces - Nature Communications, 2014 more
2010
R. Zhu, S. Howorka, J. Pröll, F. Kienberger, J. Preiner, J. Hesse, A. Ebner, V. Pastushenko, H. Gruber, P. Hinterdorfer - Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns - Nature Nanotechnology, 2010 more
2009
J. Preiner, N. Losilla, A. Ebner, P. Annibale, F. Biscarini, R. Garcia, P. Hinterdorfer - Imaging and detection of single molecule recognition events on organic semiconductor surfaces - Nano Letters , Vol. 9, No. 2, 2009 more
2009
A. Dulebo, J. Preiner, F. Kienberger, G. Kada, C. Rankl, L. Chtcheglova, C. Lamprecht, D. Kaftan, P. Hinterdorfer - Second Harmonic Atomic Force Microscopy Imaging of Live and Fixed Mammalian Cells - Ultramicroscopy, 2009 more
2009
R. Zhu, A. Ebner, M. Kastner, J. Preiner, S. Howorka, P. Hinterdorfer - Topography and Recognition Imaging of Protein-Patterned Surfaces Generated by AFM Nanolithography - ChemPhysChem, 2009 more
2008
J. Tang, H. Badelt-Lichtblau, A. Ebner, J. Preiner, B. Kraxberger, H. Gruber, U. Sleytr, N. Gelbmann, P. Hinterdorfer - Fabrication of Highly Ordered Gold Nanoparticle Arrays Templated by Crystalline Lattices of Bacterial S-Layer Protein - ChemPhysChem, 2008 more
2008
H. Artelsmair, F. Kienberger, A. Tinazli, R. Schlapak, R. Zhu, J. Preiner, J. Wruss, M. Kastner, N. Saucedo-Zeni, M. hoelzl, C. Rankl, W. Baumgartner, S. Howorka, D. Blaas, H. Gruber, R. Tampe, P. Hinterdorfer - Atomic force microscopy-derived nanoscale chip for the detection of human pathogenic viruses.… more
2008
J. Preiner - The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation - BIOMATERIALS, 2008 more
2008
J. Preiner - The surface properties of nanocrystalline diamond and nanoparticulate diamond powder and their suitability as cell growth support surfaces - BIOMATERIALS, 2008 more
2007
J. Preiner, J. Tang, V. Pastushenko, P. Hinterdorfer - Higher Harmonic Atomic Force Microscopy: Imaging of Biological Membranes in Liquid - PHYSICAL REVIEW LETTERS, 2007 more
2007
J. Preiner, H. Janovjak, C. Rankl, H. Knaus, D. Cisneros, A. Kedrov, D. Müller, P. Hinterdorfer - Free energy of membrane protein unfolding derived from single-molecule force measurements - BIOPHYSICAL JOURNAL, 2007 more
2007
E. Rebollar, I. Frischauf, M. Olbrich, T. Peterbauer, S. Hering, J. Preiner, P. Hinterdorfer, C. Romanin, J. Heitz - Proliferation of aligned mammalian cells on laser-nanostructured polystyrene - BIOMATERIALS, 2007 more