Project

Transplant

Project

Sep 2013 - dato
Within the Regio 13 project "Transplant - markers for humoral and cellular rejection after renal transplantation" (Lead: Blutzentrale of the OÖRK) we research whether and how next-generation sequencing (NGS) of B and T cell receptors to suitable to examine the state of kidney grafts quickly and more specifically. The goal is a significant improvement in graft monitoring and increasing the life span of transplanted organs.

The goal of members of the Bioinformatics research group in this project is the development and implementation of algorithms for the assignment of gene sequences to specific gene groups in order to make a statement about the genetic variation spectrum of existing immune cells. Based on data from the IMGT database of one or more dominant clones are identified; if the frequency of a clone differs significantly from others, then is a sign that either a directed (e.g. organ rejection) or an undirected (e.g. lymphoma) proliferation of a B or T cell is detected.

Research program

Auftragsprojekt


2015
M. Danzer, J. Weinberger, R. Jimenez-Heredia, S. Schaller, S. Süssner, S. M. Winkler, J. Sunzenauer, R. Oberbauer, H. Steitzer, C. Gabriel - Profiling the T- and B-cell receptor repertoire of a patient with acute kidney rejection by high-throughput sequencing - Proceedings of the 29th European Immunogenetics… more
2014
S. Schaller, J. Weinberger, M. Danzer, S. M. Winkler - ImmunExplorer: A Framework for NGS-based Characterization and Visualization of the Human Immune System - Proceedings of the 22nd Annual International Conference on Intelligent Systems for Molecular Biology (ISMB), Boston, United States of America,… more
2014
S. Schaller, J. Weinberger, M. Danzer, C. Gabriel, R. Oberbauer, S. M. Winkler - Mathematical Modeling of the Diversity in Human B and T Cell Receptors using Machine Learning - Proceedings of the 26th European Modeling and Simulation Symposium EMSS 2014, Bordeaux, France, 2014 more
2014
J. Weinberger, R. Jimenez-Heredia, S. Schaller, M. Danzer, J. Sunzenauer, S. Süssner, H. Polin, S. M. Winkler, R. Oberbauer, C. Gabriel - Next-generation sequencing based receptor repertoire analysis reveals that expanded B- and T-cells can be found in renal tissue as well as in peripheral blood - Proceedings… more